Lenalidomide-Br |
| Catalog No.GC38579 |
레날리도마이드-Br(화합물 41)은 E3 유비퀴틴 리가제에 대한 세레블론(CRBN) 리간드 레날리도마이드의 유사체이며 CRBN 단백질 모집에 사용됩니다. 레날리도마이드-Br은 링커에 의해 단백질에 대한 리간드에 연결되어 PROTAC STAT3 분해자 SD-36과 같은 PROTAC를 형성할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093387-36-9
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-Br (Compound 41) is the Lenalidomide-based ligand. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. [2]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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