MZ1 |
| Catalog No.GC18729 |
MZ1 es un PROTAC conectado por ligandos para von Hippel-Lindau y BRD4. MZ1 induce potente y rápidamente la eliminación reversible, duradera y selectiva de BRD4 sobre BRD2 y BRD3. Kds de 382/120, 119/115 y 307/228 nM para BRD4 BD1/2, BRD3 BD1/2 y BRD2 BD1/2, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1797406-69-9
Sample solution is provided at 25 µL, 10mM.
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MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 uM. At concentrations of 2-10 uM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.
Review for MZ1
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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