MZ1 |
| Catalog No.GC18729 |
MZ1은 von Hippel-Lindau 및 BRD4에 대한 리간드로 연결된 PROTAC입니다. MZ1은 BRD2 및 BRD3에 비해 BRD4의 가역적이고 오래 지속되며 선택적인 제거를 강력하고 신속하게 유도합니다. BRD4 BD1/2, BRD3 BD1/2 및 BRD2 BD1/2에 대해 각각 382/120, 119/115 및 307/228 nM의 Kds.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1797406-69-9
Sample solution is provided at 25 µL, 10mM.
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MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 uM. At concentrations of 2-10 uM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.
Review for MZ1
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
Review for MZ1
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