TL 12-186 |
| Catalog No.GC50484 |
TL 12-186 es un degradador de PROTAC multiquinasa dependiente de Cereblon. Las multiquinasas incluyen CDK, BTK, FLT3, Aurora quinasas, TEC, ULK, ITK, et al. TL 12-186 inhibe CDK2/ciclina A (IC50\u003d73 nM) y CDK9/ciclina T1 (IC50\u003d55 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250025-88-6
Sample solution is provided at 25 µL, 10mM.
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PROTAC® comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide . Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines. Negative control TL 13-27 is also available. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID:29129717
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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