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VH 032, phenol

Catalog No.GC50607

VH 032, el fenol es el ligando VHL basado en VH032. VH 032, el fenol se puede conectar al ligando de la proteÍna mediante un enlazador para formar PROTAC.

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VH 032, phenol Chemical Structure

Cas No.: 2244684-42-0

Tamaño Precio Disponibilidad Cantidad
50 mg
657,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Comm. 8 830 PMID:29018234

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