dMCL1-2 |
| Catalog No.GC35882 |
dMCL1-2 es un PROTAC potente y selectivo de la leucemia de células mieloides 1 (MCL1) (miembro de la familia Bcl-2) basado en Cereblon, que se une a MCL1 con una KD de 30 nM. dMCL1-2 activa la maquinaria de apoptosis celular por degradaciÓn de MCL1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2351218-88-5
Sample solution is provided at 25 µL, 10mM.
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dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1]. KD: 30 nM (MCL1)[1]
[1]. Papatzimas JW, et al. From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1). J Med Chem. 2019 Jun 13;62(11):5522-5540.
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