GPCR/G protein

CHU-128 is an effective and selective GLP-1R agonist.

Berobenatide acetate (PF-08653944 acetate; MET-097 acetate) is a GLP-1R agonist that exerts functional regulation of GLP-1R biased toward the Gs protein signaling pathway.

Poterepatide (HDM1005) is a long-acting GLP-1R/GIPR peptide dual agonist.

IUB0271 hydrochloride (acyl-GIP hydrochloride) is a glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist with blood-brain barrier permeability.

Survodutide (BI 456906) sodium is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC 50 s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively.

LY237 is a potent GPR84 full agonist, with EC 50 values of 0.189 nM and 0.07 nM in cAMP inhibition assay and calcium flux assay, respectively.

RTI-122 dihydrochloride is a selective, blood-brain barrier-permeable GPR88 agonist ( cAMP EC 50 =11 nM), with EC 50 values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([ 35 S]GTPγS assay).

FCH-2296413 is a potent and selective hydroxycarboxylic acid receptor ( HCAR ) agonist with an EC 50 of 4.4-8.6 nM.

Lanerkitug (FUT8-KO) (BAY3375968 (FUT8-KO)) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out.

Minokitug is a humanized monoclonal antibody targeting the CCR2 protein.

Histamine glutarimide (XC8) is an orally active anti-asthma agent.

ST45177901 is a CC chemokine receptor 4 ( CCR4 ) antagonist.

S-531011 (FUT8-KO) is an anti- CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out.

ECL1i TFA is an allosteric, selective CCR2 inhibitor.

Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody.

Anti-Mouse/Human CXCL12 Antibody (K15C) is an antibody targeting SDF-1/CXCL12.

Anti-Mouse CXCR6 Antibody (Cx6Mab-1) is a monoclonal antibody targeting mouse CXC chemokine receptor 6 ( mCXCR6 ), with a K D of 1.7 nM against CHO/mCXCR6-overexpressing cells.

Anti-Mouse CXCL16 Antibody (12-81) is an antibody targeting mouse CXCL16.

Anti-Mouse CXCL10 Antibody (1F11) is a mouse CXCL10 antibody.

Anti-Mouse CCL5 Antibody (R6G9) is a neutralizing agent that binds to CCL5 to inhibit its chemotactic activity towards CD4 + T cells [1] [2] .Anti-Mouse CCL5 Antibody (R6G9) does not suppress CD4 + T cell migration towards infection-derived liver cells, reduce CD4 + T cell hepatic accumulation, or impair CD4 + T cell migratory capacity [1] .Anti-Mouse CCL5 Antibody (R6G9) serves as a tool to assess CCL5 ’s role in in vivo target cell killing by LCMV-specific CD8 + effector T cells [2] .Anti-Mouse CCL5 Antibody (R6G9) can be used for the research of malaria infection and lymphocytic choriomeningitis virus infection [1] [2] .

Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) is an antibody targeting CXCR3, which specifically binds to an epitope within amino acid residues 23 to 44 of human CXCR3 [1] .

CCX-777 formic is an orthosteric binder and partial agonist of CXCR7/ACKR3.

Sphingomab (LT1002) is a mouse-derived IgG1 κ monoclonal antibody and also an inhibitor targeting S1P, with high affinity for S1P and a K d value of 0.03 ± 0.002 nM.

Peptide R54 acetate (Pep R54 acetate) is a CXCR4 antagonist.