Salidroside (Synonyms: Rhodioloside) |
رقم الكتالوجGN10127
One-Click Copy Product Info
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Salidroside is a tyrosol glycoside primarily found in the roots of Rhodiola species, exhibiting a wide range of biological and pharmacological properties, including anti-cancer, antioxidant, anti-aging, anti-diabetic, anti-hypertensive, anti-inflammatory, and immunomodulatory effects.
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Cas No.: 10338-51-9
Sample solution is provided at 25 µL, 10mM.
Salidroside is a tyrosol glycoside primarily found in the roots of Rhodiola species, exhibiting a wide range of biological and pharmacological properties, including anti-cancer, antioxidant, anti-aging, anti-diabetic, anti-hypertensive, anti-inflammatory, and immunomodulatory effects. Salidroside can improve muscle nutrition by increasing the expression of mTOR, p-mTOR, and MyHC[1]. It alleviates cachexia symptoms in a mouse model of cancer cachexia by activating the mTOR signaling pathway[1]. Furthermore, salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy[2]. Its anti-cancer activity is primarily due to the inhibition of the PI3K/AKT, JAK/STAT, and MEK/ERK pathways, as well as the activation of cell apoptosis and autophagy[3].
In vitro, salidroside significantly increases the expression of mTOR, p-mTOR, and MyHC in C2C12 myotubes and can effectively rescue the downregulation of mTOR, p-mTOR, and MyHC expression induced by tumor necrosis factor-alpha[1]. Salidroside (10, 25, and 50µM) significantly prevents MPP+-induced cytotoxicity and reverses the reduction in dopamine, HVA, and DOPAC levels induced by MPTP in the striatum[2]. Additionally, salidroside (100µM) inhibits the activity of prolyl endopeptidase (PEP), an enzyme associated with learning and memory, by 10.6±1.9%[4].
In vivo, salidroside (120 mg/kg/day; i.p.) significantly maintains fat mass and increases lean body mass, especially the mass of the gastrocnemius muscle, indicating a notable improvement in the main features of cancer-associated cachexia in mice[1]. Salidroside (10/20/40 mg/kg/day) also induces a mouse model of testicular damage[5].
References:
[1] Chen X, et al. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activatingmTOR signalling. J Cachexia Sarcopenia Muscle. 2016 May;7(2):225-32.
[2]Li R, et al. Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy. Oxid Med Cell Longev. 2019 Sep 10; 2019: 9341018.
[3] Zhifeng Z , Jing H , Jizhou Z ,et al.Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system[J].Drug Design Development & Therapy, 2018, 12:1479-1489.
[4] Fan W, et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401.
[5] Wang Z, et al. Salidroside Ameliorates Furan-Induced Testicular Inflammation in Relation to the Gut-Testis Axis and Intestinal Apoptosis. J Agric Food Chem. 2023 Nov 9.
| Cell experiment [1]: | |
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Cell lines |
MN9D cells |
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Preparation Method |
MN9D cells were cultured in RPMI medium with 10% FBS in a humidified atmosphere incubator of 5% CO2 at 37°C. The cells were pretreated with Salidroside(10, 25, and 50 µM) for 24 h and incubated with 200 µM of MPP+ for an additional 24 h based on a previous dose-effect study |
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Reaction Conditions |
0, 25, 50 µM; 24 h |
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Applications |
200 µM of MPP+ remarkably reduced the cell viability, and Salidroside (10, 25, and 50 µM) markedly prevented the cell toxicity induced by MPP+. |
| Animal experiment [2]: | |
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Animal models |
BABL/c and C57BL/6 mice |
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Preparation Method |
BABL/c mice were inoculated with CT-26 cells (1.0×106/100 µL), while C57BL/6 mice with LLC cells (7×105/100 µL), both of them were injected s.c. into the right flank. Nine days after inoculation, tumours were palpable (about 5 mm in diameter) in BABL/c and C57BL/6 mice, respectively. Treatments were given i.p. with the control group, salidroside (60 mg/kg/day), and salidroside (120 mg/kg/day) for 25 days in BABL/c tumour model, while for 20 days in C57BL/6 model. |
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Dosage form |
60 mg/kg/day、120 mg/kg/day; i.p. |
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Applications |
salidroside had an effective anti-cachexia activity in CAC models in vivo, including increasing quality of life and prolonging survival time. |
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References: [1]Li R, et al. Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy. Oxid Med Cell Longev. 2019 Sep 10; 2019: 9341018. | |
| Cas No. | 10338-51-9 | SDF | |
| المرادفات | Rhodioloside | ||
| Chemical Name | (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol | ||
| Canonical SMILES | C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O | ||
| Formula | C14H20O7 | M.Wt | 300.3 |
| الذوبان | ≥ 30mg/mL in DMSO,≥100 mg/mL in Water.Measured | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.33 mL | 16.65 mL | 33.3 mL |
| 5 mM | 666 μL | 3.33 mL | 6.66 mL |
| 10 mM | 333 μL | 1.665 mL | 3.33 mL |
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Quality Control & SDS
- View current batch:
- Purity: >98.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)