GLPBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Research Areas

Products Related to Cell Cycle/Checkpoint(1447)

  • GC79143 structure
    GC79143BRD4-IN-12
    CAS: 3112325-99-9
    Purity: >98%

    BRD4-IN-12 is a potent and orally active BRD4 inhibitor with an IC 50 of 7.9 nM.

  • GC79149 structure
    GC79149WX2-43
    CAS: 723754-14-1
    Purity: >99.00%

    WX2-43 is a PRMT5-KLF4 inhibitor ( K d of 11.0 nM).

  • GC79976 structure
    GC79976Chitosan oligosaccharide (MW 2000)
    Purity: >98.00%

    Chitosan oligosaccharide (MW 2000) is a natural oligomer derived from chitosan, with a molecular weight of 2000 Da.

  • GC79994 structure
    GC79994Cy5-Paclitaxel bromide
    Purity: >92.50%

    Cy5-Paclitaxel bromide is a fluorescently labeled drug probe formed by conjugating the fluorescent dye Cy5 (Cyanine 5) with the chemotherapeutic agent Paclitaxel, which is used to track the cellular uptake, subcellular distribution and drug delivery process of Paclitaxel.

  • GC80482 structure
    GC80482Carba1
    CAS: 2635394-10-2
    Purity: >98.00%

    Carba1 is a bifunctional Carbazole derivative that activates nicotinamide phosphoribosyltransferase ( NAMPT ) and enhances NAD biosynthesis.

  • GC80850 structure
    GC80850Gartisertib-d 8
    CAS: 1792214-00-6
    Purity: >98%

    Gartisertib -d 8 (VX-803-d 8 ) is the deuterium labeled Gartisertib.

  • GC80874 structure
    GC80874ARN25699
    Purity: >98%

    ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.

  • GC80888 structure
    GC80888PROTAC PLK1 Degrader-2
    Purity: >99.00%

    PROTAC PLK1 Degrader-2 is a peptide-based N-end rule PLK1 mini-PROTAC.

  • GC80890 structure
    GC80890NEK7 degrader-3
    CAS: 3119435-52-5
    Purity: >98%

    NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC 50 of 33.1 nM.

  • GC80891 structure
    GC80891NK7-902 diTFA
    Purity: >99.50%

    NK7-902 diTFA is a selective and orally active CRBN-dependent NEK7 molecular glue degrader with K d values of 1.5 and 2.6 μM for hNEK7 and mNEK7.

  • GC80896 structure
    GC80896PROTAC D16-M1P2
    Purity: >98%

    PROTAC D16-M1P2 is an orally active CRBN -mediated selective PKMYT1 PROTAC degrader, with a DC 50 of 0.7 nM in CCNE1-amplified HCC1569 breast cancer cells.

  • GC80916 structure
    GC80916ZX079
    CAS: 3124583-65-6
    Purity: >98%

    ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC 50 value of 0.035 nM and a CBP DC 50 value of < 0.02 nM.

  • GC80919 structure
    GC80919AURKA-IN-4
    CAS: 89575-11-1
    Purity: >99.50%

    AURKA-IN-4 is a Capsaicin -derived molecular glue targeting AURKA-PHB2, and acts as an inhibitor of Aurora kinase A ( AURKA ) and PHB2.

  • GC80921 structure
    GC80921CCT400028
    Purity: >98.00%

    CCT400028 is a PROTACs -class degrader that targets the Aurora A (AURKA) kinase.

  • GC80928 structure
    GC80928NP1192
    CAS: 2966791-41-1
    Purity: >99.00%

    NP1192 is a potent, selective PROTAC NAT10 degrader.

  • GC80940 structure
    GC80940dIRF4-2
    CAS: 3136609-62-3
    Purity: >99.00%

    dIRF4-2 is a selective IRF4 PROTAC degrader with a DC 50 value of 2.2 μM.

  • GC81431 structure
    GC81431(S,S,S)-Icafolin-methyl
    CAS: 2254813-53-9
    Purity: >99.50%

    (S,S,S)-Icafolin-methyl is an isomer of Icafolin-methyl.

  • GC81434 structure
    GC81434RAS activator compound 1
    CAS: 1579978-17-8
    Purity: >98.50%

    RAS activator compound 1 (Compound 7c) is a RAS activator targeting the guanine nucleotide exchange factor (GEF) son of sevenless homologue 1 ( SOS1 ).

  • GC81443 structure
    GC81443E8431
    CAS: 2419580-01-9
    Purity: >97.00%

    E8431 is a DCSTAMP antagonist with an IC 50 value of 775.8 nM for osteoclastogenesis.

  • GC81460 structure
    GC81460BTX-6654 formate
    Purity: >98.50%

    BTX-6654 formate is a SOS1 PROTAC degrader.

  • GC81467 structure
    GC814672,6-Dibromo-4-(hydroxymethyl)phenol
    CAS: 2316-62-3
    Purity: >98.00%

    2,6-Dibromo-4-(hydroxymethyl) phenol (Compound 5) acts as a selective inhibitor of Saccharomyces cerevisiae glucose-6-phosphate dehydrogenase, with an IC 50 value of 50.2 μM, and shows no activity against Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase [1] .

  • GC81468 structure
    GC81468MS102
    CAS: 3058587-77-9
    Purity: >98%

    MS102 is an orally active ubiquitin specific peptidase 2 ( USP2 ) inhibitor with an IC 50 of 5.46 μM.

  • GC81479 structure
    GC81479SMARCA2-IN-10
    CAS: 82131-85-9
    Purity: >96.00%

    SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor ( IC 50 =17.676 μM).

  • GC81480 structure
    GC81480FHD-909
    CAS: 3008577-34-9
    Purity: >98%

    FHD-909 (LY4050784) is an orally active and selective SMARCA2 (BRM) ATPase inhibitor.