GLPBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Research Areas

Products Related to Cell Cycle/Checkpoint(1447)

  • GC81495 structure
    GC81495Anti-Mouse VISTA Antibody (8G8)
    Purity: >98.00%

    Anti-Mouse VISTA Antibody (8G8) reacts with mouse VISTA.

  • GC81513 structure
    GC81513SMARCA2/4-ligand-8
    CAS: 2380272-41-1
    Purity: >99.50%

    SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 [1] .

  • GC81514 structure
    GC81514PROTAC SMARCA2 degrader-35
    CAS: 3032998-97-0
    Purity: >98%

    PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC 50 < 0.1 μM for SMARCA2.

  • GC81526 structure
    GC81526Delpacibart zotadirsen
    CAS: 2929240-20-8
    Purity: >92.50%

    Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin.

  • GC81532 structure
    GC81532Auristatin S TFA
    Purity: >99.00%

    Auristatin S TFA is a potent Auristatin payload.

  • GC81533 structure
    GC81533PE-E2K
    CAS: 3105822-56-5
    Purity: >98.00%

    PE-E2K is a derivative of Eribulin and can be used as an ADC toxin molecule [1] .

  • GC81534 structure
    GC81534MMA-NODAGA TFA
    Purity: >98.00%

    MMA-NODAGA TFA is a chelator for site-specific labeling of targeting proteins containing unpaired cysteine.

  • GC81554 structure
    GC81554CP05
    CAS: 1824650-30-7
    Purity: >97.00%

    CP05 is a peptide that specifically recognizes an exosome surface marker ( CD63 ).

  • GC81555 structure
    GC81555GPLGVRGC
    CAS: 1257658-47-1
    Purity: >98.00%

    GPLGVRG C is a cysteine-tagged variant of GPLGVRG.

  • GC81597 structure
    GC81597Momilactone B
    CAS: 51415-08-8
    Purity: >99.00%

    Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC 50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC 50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase.

  • GC81614 structure
    GC81614Zotadirsen
    Purity: >98.00%

    Zotadirsen is the core component of the AOC drug Delpacibart zotadirsen (AOC1044), consisting of a phosphorodiamidate morpholino oligonucleotide (PMO) targeting exon 44 of the dystrophin gene and an SMCC linker.

  • GC81619 structure
    GC81619(S)-Bleximenib
    CAS: 2654081-27-1
    Purity: >96.00%

    (S)-Bleximenib (Compound 28) ((S)-JNJ-75276617) is an isoform of Bleximenib.

  • GC81620 structure
    GC81620Auristatin E-d 8
    Purity: >99.00%

    Auristatin E-d 8 is the deuterium labeled Auristatin E.

  • GC81621 structure
    GC81621Mertansine- 13 C,d 3
    Purity: >98%

    Mertansine - 13 C,d 3 (DM1- 13 C,d 3 ) is the 13 C- and deuterium labeled Mertansine.

  • GC81674 structure
    GC81674MKI-3
    CAS: 3084702-28-0
    Purity: >98%

    MKI-3 is a selective microtubule-associated serine/threonine kinase-like ( MASTL ) inhibitor with an IC 50 of 5.72 nM and a K d of 1.89 nM.

  • GC81675 structure
    GC81675MKI-2 hydrochloride
    Purity: >99.50%

    MKI-2 hydrochloride is a selective MASTL inhibitor with an IC 50 of 37.44 nM.

  • GC81684 structure
    GC81684CK37
    CAS: 1001478-90-5
    Purity: >98%

    CK37 is a competitive choline kinase-α inhibitor.

  • GC81777 structure
    GC81777ABS-752 hydrochloride
    CAS: 2922884-90-8
    Purity: >98.50%

    ABS-752 hydrochloride is an orally active prodrug targeting CRBN-modulating molecular glue with selectivity in protein degradation.

  • GC81879 structure
    GC81879NCP26 TFA
    Purity: >99.50%

    NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).

  • GC81880 structure
    GC81880OSU-2S TFA
    Purity: >98.00%

    OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).

  • GC90366 structure
    GC90366Dolastatin 15 (trifluoroacetate salt)
    Purity: >98.00%

    Ein Peptid mit antikarzinogener Aktivität

  • GC90538 structure
    GC90538Mca-RPPGFSAFK(Dnp)-OH (trifluoroacetate salt)
    Purity: >95.00%

    Ein fluorogenes Substrat für ECE-1

  • GC90554 structure
    GC90554E70K (trifluoroacetate salt)
    Purity: >98.00%

    Ein Peptid-Inhibitor der CXCL8-GAG-Interaktion

  • GC90559 structure
    GC90559Mca-KPLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt)
    CAS: 1392300-20-7
    Purity: >95.00%

    Ein fluorogenes Substrat für MMPs