Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(74)
- DNA Methyltransferase(43)
- HDAC(249)
- Histone Acetyltransferases(98)
- Histone Demethylases(120)
- Histone Methyltransferase(277)
- HIF(127)
- JAK(188)
- PARP(162)
- Pim(35)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(87)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(292)
- MicroRNA(33)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(16)
- METTL3(4)
- WDR5(8)
- TET Protein(2)
- HuR(2)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1939)
- GC91565GSK199 analog (hydrochloride)CAS: 2048226-46-4Purity: >95.00%
GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.
- GC91622KAT8 Inhibitor 19CAS: 28532-21-0Purity: >98.00%
KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).
- GN10040DehydrocorydalineCAS: 30045-16-0Purity: >98.00%
Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma.
- GN10308Chlorogenic acidCAS: 327-97-9Purity: >98.00%
Chlorogensäure ist eine wichtige phenolische Verbindung in Kaffee und Tee.
- GN10347Nicotinamide (Vitamin B3)CAS: 98-92-0Purity: >99.50%
Nicotinamide (Vitamin B3) ist ein Amid-Derivat von Vitamin B3. Nicotinamide (Vitamin B3) hemmt die Aktivität von SIRT1 (IC 50 : 50-180 μM) und SIRT2 (IC 50 : 2 μM). Zudem steigert Nicotinamide den Gehalt an NAD + , ATP und ROS in Zellen.
- GN10357ParthenolideCAS: 20554-84-1Purity: >98.00%
Parthenolide ist ein NF-κB-Inhibitor mit IC 50 -Werten für Eca109-, KYSE-510-, SiHa- und MCF-7-Zellen von ungefähr 10.3, 13.3, 8.42 und 9.54μM nach 48 Stunden.
- GN10452PaeoniflorinCAS: 23180-57-6Purity: >98.00%
Paeoniflorin is a pinane monoterpene glycoside extracted from the roots of Paeonia plants of the Ranunculaceae family, possessing multiple biological activities.
- GN106295,7-dihydroxychromoneCAS: 31721-94-5Purity: >99.00%
5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC91148 | JAK Inhibitor 31 | 2891469-99-9 | >98.00% | |
Ein JAK2-Inhibitor | ||||
| GC91389 | J27644 | - | >95.00% | |
J27644 ist ein Inhibitor der Histondeacetylase 6 (HDAC6; IC50 = 10 nM). | ||||
| GC91435 | YCH1899 | - | >98.00% | |
YCH1899 ist ein Inhibitor von Poly(ADP-Ribose) Polymerase 1 (PARP1) und PARP2 (IC50s = 1). Es ist selektiv für PARP1 und PARP2 gegenüber PARP3, -4, -5A, -5B, -6, -7, -10 und -12 (IC50s = 1-14.1 nM). | ||||
| GC91506 | Bayer 18 | 1251752-12-1 | >98.00% | |
Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM). | ||||
| GC91565 | GSK199 analog (hydrochloride) | 2048226-46-4 | >95.00% | |
GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199. | ||||
| GC91602 | PFI-6 | 2675452-91-0 | >95.00% | |
PFI-6 is a chemical probe for the YEATS domain-containing proteins MLLT1 and MLLT3 (IC50s = 140 and 160 nM, respectively). | ||||
| GC91622 | KAT8 Inhibitor 19 | 28532-21-0 | >98.00% | |
KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM). | ||||
| GC91689 | TG46 | 936091-15-5 | >98.00% | |
TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM). | ||||
| GN10030 | Fisetin | 528-48-3 | >98.00% | |
Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities. | ||||
| GN10040 | Dehydrocorydaline | 30045-16-0 | >98.00% | |
Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma. | ||||
| GN10114 | Oroxin A | 57396-78-8 | >98.00% | |
| GN10308 | Chlorogenic acid | 327-97-9 | >98.00% | |
Chlorogensäure ist eine wichtige phenolische Verbindung in Kaffee und Tee. | ||||
| GN10347 | Nicotinamide (Vitamin B3) | 98-92-0 | >99.50% | |
Nicotinamide (Vitamin B3) ist ein Amid-Derivat von Vitamin B3. Nicotinamide (Vitamin B3) hemmt die Aktivität von SIRT1 (IC 50 : 50-180 μM) und SIRT2 (IC 50 : 2 μM). Zudem steigert Nicotinamide den Gehalt an NAD + , ATP und ROS in Zellen. | ||||
| GN10357 | Parthenolide | 20554-84-1 | >98.00% | |
Parthenolide ist ein NF-κB-Inhibitor mit IC 50 -Werten für Eca109-, KYSE-510-, SiHa- und MCF-7-Zellen von ungefähr 10.3, 13.3, 8.42 und 9.54μM nach 48 Stunden. | ||||
| GN10413 | Agrimol B | 55576-66-4 | >99.50% | |
| GN10442 | Curculigoside | 85643-19-2 | >99.50% | |
| GN10452 | Paeoniflorin | 23180-57-6 | >98.00% | |
Paeoniflorin is a pinane monoterpene glycoside extracted from the roots of Paeonia plants of the Ranunculaceae family, possessing multiple biological activities. | ||||
| GN10473 | Ginkgolide C | 15291-76-6 | >98.00% | |
| GN10518 | Chitosamine hydrochloride | 66-84-2 | >98.00% | |
| GN10584 | Ginsenoside Rk1 | 494753-69-4 | >98.00% | |
| GN10627 | Atractylenolide I | 73069-13-3 | >98.00% | |
| GN10629 | 5,7-dihydroxychromone | 31721-94-5 | >99.00% | |
5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat. | ||||
| GN10669 | Glucosamine sulfate | 29031-19-4 | >98.00% | |
| GP10020 | Histone-H2A-(107-122)-Ac-OH | - | >98.00% | |
Histone-H2A peptide | ||||