4α-Phorbol 12-myristate 13-acetate (Synonyms: 4α-PMA) |
| Catalog No.GC18535 |
4α-Phorbol 12-myristate 13-acétate est une forme inactive de TPA et est utilisé comme contrÔle négatif pour les événements activés par le TPA.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 63597-44-4
Sample solution is provided at 25 µL, 10mM.
Phorbol 12-myristate 13-acetate is a phorbol ester that is commonly used to activate certain types of PKC, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. 4α-PMA is a structural analog of PMA that does not activate PKC. It is used as a negative control for PMA signaling through PKC.
References:
[1]. Blumberg, P.M. Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads Memorial Award Lecture Cancer Research 48(1), 1-8 (1988).
[2]. Fischer, S.M., Patrick, K.E., Lee, M.L., et al. 4β- and 4α-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms Cancer Res. 51(3), 850-856 (1991).
[3]. Savage, M.J., Trusko, S.P., Howland, D.S., et al. Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester Journal of Neuroscience 18(5), 1743-1752 (1998).
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *