5J 4 |
Catalog No.GC50179 |
5J 4 est un puissant inhibiteur de CRAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 827001-82-1
Sample solution is provided at 25 µL, 10mM.
Calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.
Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110 PMID:24307733
Average Rating: 5
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