Accueil>>Signaling Pathways>> Membrane Transporter/Ion Channel>> CRAC Channel>>5J 4

5J 4

Catalog No.GC50179

5J 4 est un puissant inhibiteur de CRAC.

Products are for research use only. Not for human use. We do not sell to patients.

5J 4 Chemical Structure

Cas No.: 827001-82-1

Taille Prix Stock Qté
10 mg
167,00 $US
En stock
50 mg
702,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.

Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110 PMID:24307733

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Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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