AF38469 |
Catalog No.GC19023 |
AF38469 est un inhibiteur de Sortiline sélectif et biodisponible par voie orale avec une valeur IC50 de 330 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1531634-31-7
Sample solution is provided at 25 µL, 10mM.
AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
AF38469 showed no inhibition or stimulation of >50% at 10 uM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of this protein[1].
References:
[1]. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.
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