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AF38469

Catalog No.GC19023

AF38469 est un inhibiteur de Sortiline sélectif et biodisponible par voie orale avec une valeur IC50 de 330 nM.

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AF38469 Chemical Structure

Cas No.: 1531634-31-7

Taille Prix Stock Qté
10mM (in 1mL DMSO)
205,00 $US
En stock
2mg
124,00 $US
En stock
5mg
186,00 $US
En stock
10mg
297,00 $US
En stock
25mg
585,00 $US
En stock
50mg
936,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.

AF38469 showed no inhibition or stimulation of >50% at 10 uM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate evaluation of the therapeutic potential of this protein[1].

References:
[1]. Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.

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