AFM-30a hydrochloride |
| Catalog No.GC66379 |
Le chlorhydrate d'AFM-30a est un puissant inhibiteur de la protéine arginine désiminase 2 (PAD2) et possède une excellente sélectivité pour PAD2. Le chlorhydrate d'AFM-30a se lie À PAD2 avec une valeur EC50 de 9,5 μM. Le chlorhydrate d'AFM-30a inhibe également la citrullination H3 avec une valeur EC50 de 0,4 μM. Le chlorhydrate d'AFM-30a peut être utilisé pour la recherche de certains cancers et de diverses maladies auto-immunes, notamment la polyarthrite rhumatoÏde (PR), la sclérose en plaques, le lupus et la colite ulcéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].
AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM[1].
AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM[1].
Cell Viability Assay[1]
| Cell Line: | HEK293T/PAD2 cells |
| Concentration: | Various concentrations |
| Incubation Time: | 24 h |
| Result: | Exhibited low cytotoxicity for cells. |
AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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