AFM-30a hydrochloride |
| Catalog No.GC66379 |
AFM-30a 염산염은 강력한 단백질 아르기닌 탈이미나제 2(PAD2) 억제제이며 탁월한 PAD2 선택성을 가지고 있습니다. 821d96072c2d58d8970e76f526b0f6b8AFM-30a 하이드로클로라이드는 9.5 μM의 EC50 값으로 PAD2에 결합합니다. 821d96072c2d58d8970e76f526b0f6b8AFM-30a 염산염은 또한 0.4 μM의 EC50 값으로 H3 시트룰린화를 억제합니다. 821d96072c2d58d8970e76f526b0f6b8AFM-30a 염산염은 특정 암 및 류마티스 관절염(RA), 다발성 경화증, 루푸스 및 궤양성 대장염을 포함한 다양한 자가 면역 질환의 연구에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].
AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM[1].
AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM[1].
Cell Viability Assay[1]
| Cell Line: | HEK293T/PAD2 cells |
| Concentration: | Various concentrations |
| Incubation Time: | 24 h |
| Result: | Exhibited low cytotoxicity for cells. |
AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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