AFM-30a hydrochloride |
| カタログ番号GC66379 |
AFM-30a 塩酸塩は、強力なタンパク質アルギニンデイミナーゼ 2 (PAD2) 阻害剤であり、優れた PAD2 選択性を持っています。 AFM-30a 塩酸塩は、EC50 値 9.5 μ で PAD2 に結合します。M. AFM-30a 塩酸塩は H3 シトルリン化も阻害し、EC50 値は 0.4 μM. AFM-30a 塩酸塩は、特定の癌や、関節リウマチ (RA)、多発性硬化症、狼瘡、潰瘍性大腸炎などのさまざまな自己免疫疾患の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].
AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM[1].
AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM[1].
Cell Viability Assay[1]
| Cell Line: | HEK293T/PAD2 cells |
| Concentration: | Various concentrations |
| Incubation Time: | 24 h |
| Result: | Exhibited low cytotoxicity for cells. |
AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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