AFMK (Synonyms: N-acetyl-N-formyl-5-Methoxykynuramine, NSC 688263) |
| Catalog No.GC41371 |
L'AFMK, métabolite antioxydant de la mélatonine, atténue les dommages oxydatifs induits par les rayons X sur l'ADN, les protéines et les lipides chez la souris. L'AFMK est un éboueur plus pauvre. Le pKa de l'AFMK au pH physiologique est de 8,7. Capacité antioxydante. L'AFMK améliore l'effet anti-tumoral de la Gemcitabine dans les cellules PANC-1 grÂce À la modulation de la voie apoptotique.
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Cas No.: 52450-38-1
Sample solution is provided at 25 µL, 10mM.
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Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK is a melatonin metabolite first identified in rat brain. AFMK has antioxidant and free radical scavenging activities in several experimental models. AFMK may also be measured in plasma as an index of melatonin synthesis and metabolism.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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