AFMK (Synonyms: N-acetyl-N-formyl-5-Methoxykynuramine, NSC 688263) |
| カタログ番号GC41371 |
メラトニンの抗酸化代謝物である AFMK は、マウスの DNA、タンパク質、脂質に対する X 線による酸化損傷を軽減します。 AFMK は貧弱なスカベンジャーです。生理的 pH での AFMK の pKa は 8.7 です。抗酸化能力。 AFMK は、アポトーシス経路の調節を通じて、PANC-1 細胞におけるゲムシタビンの抗腫瘍効果を改善します。
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Cas No.: 52450-38-1
Sample solution is provided at 25 µL, 10mM.
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Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK is a melatonin metabolite first identified in rat brain. AFMK has antioxidant and free radical scavenging activities in several experimental models. AFMK may also be measured in plasma as an index of melatonin synthesis and metabolism.
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