Accueil>>Signaling Pathways>> GPCR/G protein>> Melatonin Receptors>>Agomelatine

Agomelatine (Synonyms: S20098)

Catalog No.GC17981

L'agomélatine (S-20098) est un agoniste spécifique des récepteurs MT1 et MT2 avec Kis de 0,1, 0,06, 0,12 et 0,27 nM pour CHO-hMT1, HEK-hMT1, CHO-hMT2 et HEK-hMT2, respectivement .

Products are for research use only. Not for human use. We do not sell to patients.

Agomelatine Chemical Structure

Cas No.: 138112-76-2

Taille Prix Stock Qté
10mM (in 1mL DMSO)
43,00 $US
En stock
5mg
36,00 $US
En stock
10mg
54,00 $US
En stock
50mg
156,00 $US
En stock
100mg
226,00 $US
En stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Avis des clients

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1].

Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned human MT1 and MT2 with Ki values of 0.09nM and 0.263nM, respectively. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C. Moreover, the administration of agomelatine counteractes the stress-induced decrease in sucrose consumption in a rat model of depression. Besides that, agomelatine exerts alleviated anxiety efficacy in a rodent model of anxiety [1].

References:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS drugs, 2006, 20(12): 981-992.

Avis

Review for Agomelatine

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Agomelatine

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.