AMY-101 (Synonyms: Cp40) |
| Catalog No.GC39697 |
AMY-101 (Cp40), un inhibiteur peptidique du composant central du complément C3 (KD = 0,5 nM), inhibe la parodontite naturelle chez les primates non humains (PNH).
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Cas No.: 1427001-89-5
Sample solution is provided at 25 µL, 10mM.
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AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].
[1]. Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215. [2]. Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450
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