AMY-101 (Synonyms: Cp40) |
| Catalog No.GC39697 |
AMY-101 (Cp40)은 중심성 보충 요소 C3의 펩티드 억제제로서 (KD = 0.5 nM), 비인간 원숭이(NHPs)에서 자연발생 치주염을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1427001-89-5
Sample solution is provided at 25 µL, 10mM.
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AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].
[1]. Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215. [2]. Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450
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