Anti-virus agent 1 (Synonyms: Anti-virus agent 1, GS-5734 isopropyl ester analog) |
| Catalog No.GC60588 |
L'agent antiviral 1 (composé 4i), un promédicament phosphoramidate du GS-5734, a une activité antivirale puissante.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1911578-83-0
Sample solution is provided at 25 µL, 10mM.
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Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734 ( Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2].
Anti-virus agent 1 (compound 4i) has antiviral activity for EBOV in HeLa cell (EC50=1845 nM), HMVEC cell (TERT-immortalized human foreskin microvascular endothelial cells; ATCC-4025; EC50=367 nM), human macrophages (EC50=297 nM). Anti-virus agent 1 has a CC50 of 21 μM in MT4 cell (human leukemia T-cell)[1].
[1]. Dustin Siegel , et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. [2]. Michael O' Neil Hanrahan Clarke, et al.Methods for treating arenaviridae and coronaviridae virus infections. US20170071964A1.
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