Rimantadine Hydrochloride (Synonyms: 1-(1-Adamantyl)ethylamine Hydrochloride, NSC 206764) |
Catalog No.GC17462
One-Click Copy Product Info
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Le chlorhydrate de Rimantadine est un médicament contre le virus de la grippe.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1501-84-4
Sample solution is provided at 25 µL, 10mM.
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Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
In a variety of tissue culture systems, rimantadine (25 μg/ml) completely suppressed the growth of dengue virus type 2 in human peripheral blood leukocytes (PBL). Rimantadine significantly inhibited dengue virus replication in cultures of rhesus monkey PBL. In virus-infected LLC-MK2 cell cultures, rimantadine decreased the production of all four types of dengue virus [1]. Rimantadine interfered with the generation of cellular immune responses. Rimantadine hydrochloride inhibited the proliferative response of human peripheral blood lymphocytes to mitogenic and antigenic stimulation. Rimantadine hydrochloride (25 μg/ml) suppressed the responses to phytohemagglutinin, pokeweed mitogen, and concanavalin A by 25, 65, and 90%, respectively. rimantadine (10 μg/ml) significantly inhibited responses to streptokinase-streptodornase, tetanus toxoid, and A2/Aichi influenza vaccine [2]. In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine (200 mg/day for 5 days) significantly reduced nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic symptoms [3].
References:
[1] Koff W C, Elm Jr J L, Halstead S B. Suppression of dengue virus replication in vitro by rimantadine hydrochloride[J]. The American journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] Koff W C, Peavy D L, Knight V. Inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[J]. Infection and immunity, 1979, 23(3): 665-669.
[3] Hayden F G, Monto A S. Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults[J]. Antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.
| Cas No. | 1501-84-4 | SDF | |
| Synonymes | 1-(1-Adamantyl)ethylamine Hydrochloride, NSC 206764 | ||
| Chemical Name | (R)-1-((1s,3R,5S,7S)-adamantan-1-yl)ethanamine hydrochloride | ||
| Canonical SMILES | N[C@H](C)[C@]1(C[C@H]2C3)C[C@@H](C2)C[C@H]3C1.Cl | ||
| Formula | C12H22ClN | M.Wt | 215.76 |
| Solubility | ≥ 21.6mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.6348 mL | 23.1739 mL | 46.3478 mL |
| 5 mM | 927 μL | 4.6348 mL | 9.2696 mL |
| 10 mM | 463.5 μL | 2.3174 mL | 4.6348 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)