AZD-5991 S-enantiomer |
| Catalog No.GC33239 |
L'énantiomère S AZD-5991 est l'énantiomère le moins actif de l'AZD-5991. L'énantiomère S AZD-5991 est un inhibiteur de Mcl-1 avec une IC50 de 6,3 μM dans le test FRET et un Kd de 0,98 μM dans le test de résonance plasmonique de surface (SPR).
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Cas No.: 2143061-82-7
Sample solution is provided at 25 µL, 10mM.
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AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
[1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341.
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