Bak BH3 |
| Catalog No.GC34263 |
Bak BH3 est dérivé du domaine BH3 de Bak, peut antagoniser la fonction de Bcl-xL dans les cellules.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.
Bak BH3 peptide antagonize the protective effects of microinjected Bcl-xL in α-Fas-treated HeLa cells, whereas a mutant Bak BH3 peptide that no longer binds Bcl-xL is inactive[1].
[1]. Holinger EP, et al. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 7;274(19):13298-304.
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