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Bak BH3

Katalog-Nr.GC34263

Bak BH3 stammt von der BH3-DomÄne von Bak ab und kann die Funktion von Bcl-xL in Zellen antagonisieren.

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Bak BH3 Chemische Struktur

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1mg
101,00 $
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5mg
304,00 $
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10mg
506,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

Bak BH3 peptide antagonize the protective effects of microinjected Bcl-xL in α-Fas-treated HeLa cells, whereas a mutant Bak BH3 peptide that no longer binds Bcl-xL is inactive[1].

[1]. Holinger EP, et al. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 7;274(19):13298-304.

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