BCRP-IN-1 |
| Catalog No.GC33099 |
BCRP-IN-1 est un inhibiteur de la protéine de résistance du cancer du sein (BCRP) avec une IC50 de 0,6 μ M sur le transporteur d'efflux BCRP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1699720-85-8
Sample solution is provided at 25 µL, 10mM.
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BCRP-IN-1 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter.
BCRP-IN-1 (Compound A) shows the potency and a potent pharmacokinetic (PK) profile in rats (lower clearance [1.54 L/h/kg] and higher bioavailability [123%]). XL388 has moderate terminal elimination half-life with t1/2s of 0.9 h and 2.0 h for 2 mg/kg (iv) and 20 mg/kg (po) in rats, respectively[1].
[1]. Li Y, et al. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2016 Jan 15;26(2):551-555.
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