Lung cancer is one of the cancers with the highest mortality rate in the world, and non-small cell lung cancer (NSCLC), as its main type, threatens people's health and longevity. Medical experts have carried out a lot of basic research on lung cancer, and have also developed many targeted drugs, but the changes in the disease are always one step ahead, and more new drugs and treatment strategies are urgently needed to deal with it.

Since its discovery in 1979, the p53 gene has been one of the focuses of oncology research. Searching the Pubmed database with p53 as the keyword can find more than 100,000 articles. In a 2017 statistic by Nature magazine, the p53 gene ranked first in the list of the most popular research genes in the past few decades by an absolute advantage.

Alzheimer's disease (AD), commonly known as Alzheimer's disease, is a progressive neurodegenerative disease with an insidious onset. Generally, the onset before the age of 65 is called Alzheimer's disease; the onset after the age of 65 is called senile dementia. The pathogenesis of AD is complex, and related studies suggest that neuritic plaques composed of extracellular β-amyloid and many other proteins are one of the main lesions, and even begin to deposit twenty years before the onset of AD patients. Scientists have developed some drugs around the mechanism of inhibiting the deposition of beta-amyloid plaques, but these can only slow the progression of the disease and cannot effectively reverse or improve the disease. Although a lot of research and achievements have been made, in fact, the root cause of AD pathogenesis is not yet clear and there is no direct and effective treatment.

Acute pancreatitis (AP) is a common clinical acute abdomen with complex etiology, with a mortality rate of 5% to 10%, and severe AP mortality as high as 20% to 30%. Way. At present, the commonly used methods for making in vivo AP animal models include pancreatic duct ligation, duodenal loop closure, pancreaticobiliary puncture and injection, pancreatic subcapsular injection, pancreaticobiliary injection combined with intravenous infusion, and bombesin in combination. Intraperitoneal injection of lipopolysaccharide, etc.

We all know that there are many types of fluorescent dyes, such as: Cyanines, SIR, Fluorescein, TAMRA, ICG, etc. Today, I will show you one of them, Cyanines. For details, please see the following:

There are two types of cyanine dyes: non-sulfonated cyanines and sulfonated cyanines. For many applications, they are interchangeable because their spectral properties are nearly identical. Both sulfonated and non-sulfonated dyes can be used to label biomolecules such as DNA and proteins. The difference between dyes is their solubility: sulfur dyes are water soluble, and they do not use organic co-solvents for marking in aqueous environments. They do not tend to aggregate in water. In some cases, one type of cyanine is required.

Streptococcus pyogenes, also known as group A streptococcus (GAS), causes a wide variety of acute infections, ranging from localized purulent infections to severe, even fatal, invasive disease. Systemic spread is usually caused by bacterial penetration of the epithelial barrier of the pharynx or damaged skin and, if not well controlled, can lead to blood and soft tissue invasion. Superficial colonization and invasive infection of GAS depend on secreted GAS virulence factors, of which cysteine protease exotoxin (SpeB) is the key. SpeB is initially an inactive zymogen that is proteolytically converted to a mature catalytically active enzyme. SpeB contributes to epidermal localization and systemic spread, but the underlying mechanisms are unknown.