Quercetin, a bioactive plant-derived flavonoid abundant in fruits and vegetables, has shown remarkable promise in fighting melanoma, a deadly skin cancer. Research has revealed that quercetin can inhibit tumor growth without toxicity, boosting antitumor immunity by modulating the tumor immune microenvironment. This natural compound has been found to increase the percentages of immune cells, suppress cell proliferation and migration, and promote phagocytosis, making it a potential therapeutic agent for enhancing the efficacy of existing melanoma treatments. With its anti-inflammatory, antioxidant, and anticancer properties, quercetin holds great potential as a complementary therapy for melanoma, offering new hope for patients seeking effective and natural solutions.

Dioscin, a natural steroidal saponin derived from Dioscorea nipponica Makino, exhibits diverse pharmacological effects, including anti-inflammatory, antioxidant, and anti-apoptotic properties. Recent research highlighted its protective role in cardiovascular and cerebrovascular systems.

Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis, a type of iron-dependent cell death implicated in various kidney diseases, including hyperuricemic nephropathy (HN). HN is a metabolic disorder characterized by elevated uric acid levels, leading to renal fibrosis and tubular necrosis.

A Novel Therapeutic Agent for Rheumatoid Arthritis, Agomelatine (AOM) is a promising pharmacological agent that has shown significant therapeutic potential in combating rheumatoid arthritis (RA), a chronic autoimmune disease characterized by inflammation and joint destruction. Recent studies have revealed AOM's efficacy in inhibiting tumor necrosis factor-alpha (TNFα) -mediated inflammation, a crucial pathway involved in RA pathogenesis.

Cinacalcet an FDA approved drug which kills bacteria by destroying bacterial membrane as well as respiratory metabolism and is used to treat secondary hyperparathyroidism and parathyroid cancer. It can also kill bacteria by producing reactive oxygen species (ROS). It was revealed by Limited Proteolysis -Small molecule mapping (LiP-SMap) that cinacalcet inhibits biofilm formation by targeting IcaR. Cinacalcet can partially remove the biofilm of drug-resistant S. aureus in an animal model it was revealed by in vitro and in vivo experiments . These findings suggest that cinacalcet has antibacterial and antibiofilm capabilities.

A ubiquitous metabolite that participates in numerous physiological processes, including transsulfuration, polyamine biosynthesis, and transmethylation is the ademetionine also known as S-adenosyl-L-methionine (AdoMet), SAM or SAMe ( Glpbio ).

A macrolide antibiotic, tylosin is active against gram-positive aerobic bacteria and mycoplasmas throughout a wide range of conditions. It is authorized for the treatment of a number of infectious disorders in cattle and poultry, including mastitis, respiratory conditions, and farm animal dysentery.

Dans les numéros précédents, nous avons présentédiverses formulations et stratégies pour la dissolution des médicaments. Parmi elles, le DMSO, qui n'est pas recommandé, a également sa place en tant que co-solvant, mais il est assez controversé.L'utilisation de ce solvant, restreinte par la FDA, est largement répandue et est hautement toxique.Quelle est son toxicité et comment l'utilisons-nous dans nos expériences ? Aujourd'hui, nous allonsvous révéler la bonne utilisation du "solvant universel" DMSO dans les expériences cellulaires et animales.

Brent R. Stockwell, l’auteur de l’origine de la ferroptose, a rédigé une revue sur les progrès de la recherche pour le 10e anniversaire de la ferroptose, publiée dans le journal Cell avec un facteur d'impact élevé de 66,85 .

Introduction: RSM-932A, also known as TCD- 717, is a ChoKα asset, which targets the mortal choline kinase nascence, an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A appears to have an altogether new medium of inhibition and is synergistic with respect to both choline and ATP. RSM-932A have in vitro inhibitory exertion in the low nanomolar range.