BPR1M97 |
| Catalog No.GC38741 |
BPR1M97 est un agoniste des récepteurs mu opioïdes (MOP) et des récepteurs de la peptide nociceptine-orphanine FQ (NOP) à double action, avec des valeurs Ki respectives de 1,8 et 4,2 nM.
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Cas No.: 2059904-66-2
Sample solution is provided at 25 µL, 10mM.
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BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects[1].
BPR1M97 (1.8 mg/kg; s.c.; once) demonstrates antinociception in a murine model of cancer pain[1]. Animal Model: Male wild-type C57BL/6 mice (25-30?g)[1]
[1]. Chao PK, et al. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, producespotent antinociceptive effects with safer properties than morphine. Neuropharmacology. 2019 Jul 3:107678.
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