VU0134992 hydrochloride |
| Catalog No.GC39667 |
Le chlorhydrate de VU0134992 est le premier bloqueur de pores du canal potassique Kir4.1, actif par voie orale et sélectif, préférant le sous-type, avec une CI50 de 0,97 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1052515-91-9
Sample solution is provided at 25 µL, 10mM.
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VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV[1].
[1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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