VU0134992 hydrochloride |
| カタログ番号GC39667 |
VU0134992 塩酸塩は、IC50 が 0.97 μM で、サブタイプ優先、経口活性、選択的 Kir4.1 カリウム チャネル ポア ブロッカーとしては初めてです。
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Cas No.: 1052515-91-9
Sample solution is provided at 25 µL, 10mM.
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VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV[1].
[1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.
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