(-)-Chaetominine (Synonyms: (-)-Chaetominine) |
カタログ番号GC45246 |
(-)-ケトミニンはアルカロイド代謝産物です。 (-)-ケトミニンは、ヒト白血病 K562 および結腸癌 SW1116 細胞株に対して細胞毒性を示します。 (-)-ケトミニンは、K562/Adr ヒト白血病細胞の PI3K/Akt/Nrf2 シグナル伝達経路を阻害することにより、MRP1 を介した薬剤耐性を低下させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 918659-56-0
Sample solution is provided at 25 µL, 10mM.
(-)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015. It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (-)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9. It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin in resistant K562 cells.
Average Rating: 5
(Based on Reviews and 17 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *