Desethyl KBT-3022 |
| Catalog No.GC32663 |
Le déséthyl KBT-3022 est le principal métabolite actif du nouvel agent antiplaquettaire, le KBT-3022.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 101001-72-3
Sample solution is provided at 25 µL, 10mM.
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Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.
Pretreatment with desethyl KBT-3022 0.1, 0.3 and 1 mg/kg, i.v. prolongs the time required to achieve thrombotic occlusion in the femoral artery and inhibits collagen-induced platelet aggregation in whole blood ex vivo, each in a dose-dependent manner. Desethyl KBT-3022 inhibits the thrombin-induced aggregation of washed platelets in a concentration-dependent manner 1-40 μM[1].
[1]. Shimazawa M, et al. Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. Eur J Pharmacol. 1997 Jun 11;328(2-3):183-9.
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