Dityrosine (hydrochloride) (Synonyms: Bityrosine, o,o-Ditryosine) |
| Catalog No.GC46134 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2716849-01-1
Sample solution is provided at 25 µL, 10mM.
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Dityrosine is a protein oxidation product that is formed by intermolecular cross-linking of two tyrosyl radicals generated from the interaction between reactive oxygen species (ROS) and tyrosine.1,2 Intragastric administration of dityrosine (320 μg/kg per day) decreases hippocampal expression of the NMDA receptor subunits Nr1, Nr2a, and Nr2b and induces memory impairments in a novel object recognition test in mice.2 It increases fasting blood glucose levels and decreases plasma insulin levels and pancreatic expression of the insulin synthesis-related genes Ins2, Pdx1, and MafA in mice.3 Increased levels of dityrosine are positively correlated with various diseases, including autism spectrum disorder, cataracts, Alzheimer's disease, Parkinson's disease, atherosclerosis, and cystic fibrosis.4,5
|1. AmadÒ, R., Aeschbach, R., and Neukom, H. Dityrosine: In vitro production and characterization. Methods Enzymol. 107, 377-388 (1984).|2. Ran, Y., Yan, B., Li, Z., et al. Dityrosine administration induces novel object recognition deficits in young adulthood mice. Physiol. Behav. 164(Pt A), 292-299 (2016).|3. Ding, Y.Y., Li, Z.Q., Cheng, X.R., et al. Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice. Amino Acids 49(8), 1401-1414 (2017).|4. Anwar, A., Abruzzo, P.M., Pasha, S., et al. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis. Mol. Autism 9, 3 (2018).|5. DiMarco, T., and Giulivi, C. Current analytical methods for the detection of dityrosine, a biomarker of oxidative stress, in biological samples. Mass Spectrom. Rev. 26(1), 108-120 (2007).
| Cas No. | 2716849-01-1 | SDF | |
| Synonymes | Bityrosine, o,o-Ditryosine | ||
| Canonical SMILES | OC1=CC=C(CC(N)C(O)=O)C=C1C2=CC(CC(N)C(O)=O)=CC=C2O.Cl.Cl | ||
| Formula | C18H20N2O6 • 2HCl | M.Wt | 433.3 |
| Solubility | DMF: 5mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,PBS (pH 7.2): 10mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3079 mL | 11.5393 mL | 23.0787 mL |
| 5 mM | 0.4616 mL | 2.3079 mL | 4.6157 mL |
| 10 mM | 0.2308 mL | 1.1539 mL | 2.3079 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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