Emedastine |
Catalog No.GC39378 |
L'émédastine est un antagoniste des récepteurs de l'histamine H1 actif par voie orale, sélectif et de haute affinité avec une valeur Ki de 1,3 nM.
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Cas No.: 87233-61-2
Sample solution is provided at 25 µL, 10mM.
Emedastine is an orally active, selective and high affinity histamine H1-receptor antagonist with a Ki value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis[1][2][3].
[1]. Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10(4):653-64. [2]. Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10(11):1859-67. [3]. Andoh T, et al. Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406(1):149-52.
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