Finerenone (Synonyms: BAY 94-8862) |
| Catalog No.GC60842 |
La finérénone (BAY 94-8862) est un antagoniste des récepteurs minéralocorticoÏdes non stéroÏdiens (MR) de troisième génération, sélectif et disponible par voie orale (IC50 = 18 nM).
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Cas No.: 1050477-31-0
Sample solution is provided at 25 µL, 10mM.
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Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease[1][2].
Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar FrÖmter (MWF) rat[1]. Animal Model: Twelve-week-old MWF rat[1]
[1]. BÄrfacker L, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7(8):1385-1403. [2]. GonzÁlez-BlÁzquez R, et al. Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress. Front Pharmacol. 2018;9:1131. Published 2018 Oct 9.
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