[Des-Arg9]-Bradykinin (Synonyms: (Des-Arg9)-BK, (Des-Arg9)-Kallidin, (Des-Arg9)-KD, RPPGFSPF-OH) |
| Catalog No.GC35015 |
La [Des-Arg9]-bradykinine est un agoniste des récepteurs de la bradykinine (B1) qui affiche une sélectivité pour les récepteurs B1 par rapport aux récepteurs B2.
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![[Des-Arg9]-Bradykinin Chemical Structure](/media/struct/GC3/GC35015.png "[Des-Arg9]-Bradykinin Chemical Structure")
Cas No.: 15958-92-6
Sample solution is provided at 25 µL, 10mM.
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[Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors.
The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively[1].
References:
[1]. Leeb-Lundberg LM, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77.
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