E3 ligase Ligand 18 |
| Catalog No.GC35932 |
E3 ligase Ligand 18 est un ligand de l'ubiquitine ligase E3. Le ligand 18 de la ligase E3 peut être connecté au ligand de la protéine par un lieur pour former des PROTAC. Les PROTAC sont des inducteurs de la dégradation médiée par l'ubiquitination des protéines favorisant le cancer.
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Cas No.: 2241669-88-3
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. VHL
[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
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