E3 ligase Ligand 18 |
カタログ番号GC35932 |
E3 リガーゼ リガンド 18 は、E3 ユビキチン リガーゼのリガンドです。 E3 リガーゼ リガンド 18 は、PROTAC を形成するリンカーによってタンパク質のリガンドに接続できます。 PROTAC は、がん促進タンパク質のユビキチン化を介した分解のインデューサーです。
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Cas No.: 2241669-88-3
Sample solution is provided at 25 µL, 10mM.
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. VHL
[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
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