PF-CBP1 hydrochloride |
| Catalog No.GC36887 |
Le chlorhydrate de PF-CBP1 est un inhibiteur hautement sélectif du bromodomaine de la protéine de liaison CREB (CBP BRD).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070014-93-4
Sample solution is provided at 25 µL, 10mM.
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PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain.Target: CREBin vitro: PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors. [1]
[1]. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96.
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