Pyrazofurin |
| Catalog No.GC37042 |
La pyrazofurine, un analogue nucléosidique de la pyrimidine ayant une activité antinéoplasique, inhibe la prolifération cellulaire et la synthèse d'ADN dans les cellules en inhibant l'uridine 5'-phosphate (UMP) synthase. La pyrazofurine est un inhibiteur actif et sensible de l'orotate-phosphoribosyltransférase avec des CI50 entre 0,06 et 0,37 μM dans les trois lignées cellulaires de carcinome épidermoÏde (SCC) Hep-2, HNSCC-14B et HNSCC-14C.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30868-30-5
Sample solution is provided at 25 µL, 10mM.
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Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase[1]. Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 µM in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C[2].
[1]. Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27. [2]. Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339.
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