GSTO-IN-2 |
| Catalog No.GC33342 |
GSTO-IN-2 est un inhibiteur de la glutathion S-transférase avec des IC50 de 3,6, 16,3 et 1,4 μM pour GSTA2, GSTM1 et GSTP1-1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1202710-57-3
Sample solution is provided at 25 µL, 10mM.
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GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1].
[1]. Chang KH, et al. Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. Chem Commun (Camb). 2006 Feb 14;(6):629-31.
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