LY3295668 (AK-01) (Synonyms: AK-01) |
| Catalog No.GC33057 |
LY3295668 (AK-01) (AK-01) est un inhibiteur de la kinase Aurora-A puissant, actif par voie orale et hautement spécifique, avec des valeurs Ki de 0,8 nM et 1038 nM pour AurA et AurB, respectivement.
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Cas No.: 1919888-06-4
Sample solution is provided at 25 µL, 10mM.
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LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.
LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].
[1]. Gong X, et al. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469.
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