MC-GGFG-DX8951 (Synonyms: MC-GGFG-DX8951) |
| Catalog No.GC39309 |
MC-GGFG-DX8951 (MC-GGFG-DX8951) est un conjugué médicament-lieur pour l'ADC. MC-GGFG-DX8951 est un dérivé de DX8951 (un inhibiteur de l'ADN topoisomérase I) avec un lieur MC-GGFG clivable par protéase. MC-GGFG-DX8951 présente une activité antitumorale et peut être utilisé pour préparer le conjugué d'anticorps DX8951 (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1600418-29-8
Sample solution is provided at 25 µL, 10mM.
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MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker[1].
[1]. Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-1545.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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