ML-030 (Synonyms: CID-11757146) |
| Catalog No.GC16072 |
ML-030 est un puissant inhibiteur de PDE4, avec une IC50 de 6,7 nM, 12,9 nM, 48,2 nM, 37,2 nM, 452 nM et 49,2 nM pour PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1 et PDE4D2, respectivement.
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Cas No.: 1013750-77-0
Sample solution is provided at 25 µL, 10mM.
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ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.
ML-030 is potent in cell-based assay with an EC50 value of 18.7 nM[1].
References:
[1]. Skoumbourdis AP, et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92.
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