MPP+-d3(iodide) |
| Catalog No.GC66401 |
MPP+-d3 (iodure) est marqué au deutérium MPP+ (iodure). L'iodure MPP+, un métabolite toxique de la neurotoxine MPTP, provoque des symptÔmes de la maladie de Parkinson dans des modèles animaux en détruisant sélectivement les neurones dopaminergiques de la substantia nigra. L'iodure MPP+ est capté par le transporteur de la dopamine dans les neurones dopaminergiques oÙ il exerce son action neurotoxique sur les mitochondries en agissant sur le complexe I de la chaÎne respiratoire. L'iodure MPP+ est également un substrat de haute affinité pour le transporteur de la sérotonine (SERT).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 207556-07-8
Sample solution is provided at 25 µL, 10mM.
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MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
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