MPP+-d3(iodide) |
| Catalog No.GC66401 |
MPP+-d3(요오드화물)은 MPP+(요오드화물)로 표시된 중수소입니다. 821d96072c2d58d8970e76f526b0f6b8신경독소인 MPTP의 독성 대사산물인 MPP+ iodide는 흑질에서 도파민 신경세포를 선택적으로 파괴하여 동물 모델에서 파킨슨병 증상을 유발합니다. 821d96072c2d58d8970e76f526b0f6b8MPP+ 요오드화물은 도파민 수송체에 의해 도파민성 뉴런으로 흡수되어 호흡 사슬의 복합체 I에 영향을 미토콘드리아에 대한 신경독성 작용을 발휘합니다. 821d96072c2d58d8970e76f526b0f6b8MPP+ 요오드화물은 또한 세로토닌 수송체(SERT)에 대한 고친화성 기질입니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 207556-07-8
Sample solution is provided at 25 µL, 10mM.
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MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
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GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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