MPP+-d3(iodide) |
| カタログ番号GC66401 |
MPP+-d3(iodide) は MPP+ (iodide) と標識された重水素です。 MPP+ ヨウ化物は、神経毒 MPTP の毒性代謝物であり、黒質のドーパミン作動性ニューロンを選択的に破壊することにより、動物モデルでパーキンソン病の症状を引き起こします。 MPP+ ヨウ化物は、ドーパミン輸送体によってドーパミン作動性ニューロンに取り込まれ、そこで呼吸鎖の複合体 I に影響を与えることにより、ミトコンドリアに神経毒性作用を発揮します。 MPP+ ヨウ化物は、セロトニントランスポーター (SERT) の高親和性基質でもあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 207556-07-8
Sample solution is provided at 25 µL, 10mM.
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MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
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